With sass as her superpower and one-liners as sharp as a laser, Penny Hofstadter, portrayed by the incomparable Kaley Cuoco in The Big Bang Theory is a comedic genius. She stole hearts and tickled funny bones throughout the beloved sitcom. Being the attractive, aspiring actress and next-door neighbor to a group of socially awkward scientists. Penny provided a refreshing contrast to the nerdy antics of the show's main characters.

Let the laughter commence, for Penny Hofstadter's comedic reign is about to take center stage! Here are some of her best quotes of all time.

10 "Oh, come on, you can't ruin a friendship with sex! That's like ruining chocolate ice cream with sprinkles!"

As the friends explore the notion of potentially jeopardizing their friendship by crossing the line into a romantic relationship. Penny playfully raises an eyebrow and delivers her unforgettable quote. Her playful yet straightforward perspective lightens the mood and adds a dose of humor to the conversation.

This showcases Penny's ability to find wit and whimsy in the intricacies of human connections. Her knack for delivering clever lines that blend humor, relatability, and a touch of absurdity is portrayed.

She effortlessly establishes herself as the group's comedic anchor. All the while providing a refreshing perspective on love and friendship.

9 "Holy Crap on a Cracker!"

One of Penny's catchphrases that is rarely mentioned is this one. In one of the scenes, Sheldon and Ramona are working on their feet when she opens the door to the guys' apartment to deliver a package that has come for them.

The phrase serves as a colorful expression of her astonishment, capturing her personality and adding a touch of comedic flair to the scene.

Penny's exuberant outburst becomes a memorable phrase that captures her lively spirit perfectly.

8 "Mrs. Cooper? Hey! It's Penny. Yeah, I think I broke your son."

Sheldon went to Penny to learn more about acting, so he could become a better professor. Eventually, Sheldon began to read their screenplay too literally. Sheldon became emotional in the middle of their lesson because the screenplay was a fictionalized account of his early years. Penny was forced to call his mother because he started crying so hard while acting.

It was a memorable quote because it showed how close Penny and Sheldon were by showing that Penny knew to call Mrs. Cooper. Penny's humorous and candid approach to sharing the news about Sheldon makes even the tense situation a laughable moment.

7 "Well, my acting teacher always said, 'Use the pain.'"

This scene unfolds with the gang gathered in the living room, with Penny sharing her amusing anecdote about her acting class. As the group leans in, captivated by Penny's storytelling prowess, she recounts her acting teacher's advice.

With a theatrical flair, she throws those lines.

Penny's quote lingers in the air, leaving her friends in awe of her ability to find levity in even the most trying situations. Her words reflect her resilient spirit and her willingness to embrace life's ups and downs with a comedic twist. It portrays how she finds humor in the face of adversity, using her quick wit to transform difficult experiences into sources of comedic inspiration.

6 "They're going to get beaten up at Walgreens."

Raj and Howard dressed up as goths in an attempt to attract women. Before that, they had to stop at Walgreens to get more makeup. However, given how ridiculous they appeared in their costumes, Penny threw this hilarious line with a little sass at them.

Penny made the scene even more comical with her own distinct dry sense of humor. She never misses a chance to seize the opportunity of eliciting some laughter. With her quip, she reminds her friends to embrace a sense of humor even in ridiculous situations or endeavors.

5 "Oh, My God. You're about to jibber-jabber about jibber-jabber!"

Some of the most iconic Penny quotes emerge while she is interacting with Sheldon. The scene is set in the laundry room, where Sheldon and Penny are alone together. Here, Penny tells Sheldon that sometimes his talks are jibber-jabbers, which he doesn't accept.

Hence, Sheldon raises the question if she even knew where the phrase came from. To which Penny responds with such exclamation. This way she reminds the audience of the importance of concise and meaningful communication which can be understood by both parties.

4 "I love him, but if he's broken, let's not get a new one."

Although Penny deeply cares for Sheldon, she also likes to tease him about being an extraterrestrial. The friendly dynamic between Sheldon and Penny includes it. Sheldon flees the room in terror when Leonard startles him after arriving from a date with Penny. At this point, Penny declares that if Sheldon is broken, she doesn't want a "new" Sheldon.

Penny's comparison of Sheldon to owning a pet is amusing because, in many ways, he requires just as much upkeep as one.

This scene emphasizes her ability to see beyond his idiosyncrasies and appreciates him for his remarkable mind and endearing quirks. This quote serves as a touching reminder of the unique connection between Penny and Sheldon.

3 "I may not be book smart, but I'm street smart. That's something you can't learn in a library."

Penny joins the gang's playful debate on book smarts versus street smarts in Sheldon and Leonard's cozy living room. With a mischievous smile, she delivers her zinger.

The room erupts in laughter, with Sheldon's bewildered expression.

Penny's clever remark showcases her quick wit and asserts her unique perspective on intelligence. She playfully acknowledges her own strengths. Highlighting the value of practical knowledge acquired through life experiences. This scene perfectly captures Penny's talent to effortlessly throw a punch line that leaves everyone in stitches.

2 "No one ever bought me drinks at a bar because my brain just popped out of my shirt."

This show frequently makes fun of Penny's attractiveness and how it enables her to get what she wants from men. Amy is receiving assistance from Bernadette and Penny to resume dating. Bernadette and Penny are discussing Amy's conservative wardrobe as she decides what to wear.

Penny responds with this comeback about her chest when Amy tries to argue that the brain is actually the sexiest organ. With this, Penny is talking about how her body features earn her more free drinks than her smarts. This is one of the most Penny-ish things Penny could ever say, giving stern awareness to her friends.

1 "In the olden days, I would have never known He was that stupid."

Penny undergoes a lot of character development over the course of the show's 12 seasons. Penny admits in season three that she isn't the same stupid blonde she was when she first moved into the building. She was now more intelligent than the men she dated.

Fans first meet Zack in this episode. He dates Penny intermittently throughout the show and is a dim-witted but kind-hearted and well-meaning guy. He actually loves science, despite his general lack of intelligence. Unfortunately, Penny has been brainwashed to realize how stupid Zack really is. This was a fantastic quote because Penny finally acknowledged her value while also admitting her past transgressions with men.