Penny and Sheldon had tremendous chemistry on The Big Bang Theory. However, fans suggest this took place because of the real connection between Jim Parsons and Kaley Cuoco, one that was especially evident given the many outtakes the two were forced to endure throughout the 12 seasons of The Big Bang Theory.

In the following we're going to take a closer look at Cuoco's relationship to Jim Parsons. As we'll reveal, the two shared some major ups, like their first experience together during auditions. However, downs also followed, which included Jim Parsons' decision to end the show.

We'll take a look back at those moments, while also putting the spotlight on their hilarious bloopers together, a compilation fans still can't get enough of.

We're also going to update fans on their current status today.

Kaley Cuoco And Jim Parsons Instantly Hit It Off When They Met At The Big Bang Theory Auditions

The chemistry between Kaley Cuoco and Jim Parsons was immediate. Speaking about her audition alongside The Hollywood Reporter, Cuoco recalls instantly connecting with Parsons, and knowing he was the perfect fit for the role of Sheldon.

"I remember sitting next to Jim in the waiting room and he had a Blackberry. It was an older phone and I remember introducing myself to him.

He said he couldn't get his Blackberry working and was talking to it. I thought, "This guy would be a hilarious Sheldon." It might have been a Nextel, I don't know what it was!"

The chemistry between the two was undeniable on-screen. Fans adored Penny and Sheldon, especially given how their friendship would evolve during the 12 seasons. However, their relationship off-camera did take a bit of a hit after Parsons decided to step away from The Big Bang Theory, without consulting his cast members first.

Cuoco was heartbroken over it, "Jim said, 'I don't think I can continue on,'" Cuoco shares. "And I was so shocked that I was literally like, 'Continue on with what?' Like, I didn't even know what he was talking about.

I looked at Chuck: 'Wow. I thought we were — I'm so blown away right now.'"

It would lead to Cuoco almost skipping out on tapings the following day, while she struggled to make eye contact with the actor. Thankfully, things were able to smoothen over throughout the final season and the two sides remain in contact these days.

Over 1 Millions Fans On YouTube Watched Compilations Of Kaley Cuoco And Jim Parsons Adorably Breaking Together

Over on YouTube, compilations featuring the cast of The Big Bang Theory breaking during scenes have millions of views.

Fans adore seeing the lighter side of the cast off-camera, and that's especially true for Kaley Cuoco and Jim Parsons. Their outtakes together have over one million views, and several have been created.

As shown in the video below, fans especially loved when the two break, and Kaley reaches for Parsons' face in the sweetest way.

As expected, fans had nothing but praise for both Cuoco and Parsons in the comments section of the video.

The top comment reads, "Everyone talks about the Penny/Sheldon chemistry, honestly I think its the Kaley/Jim chemistry coming to life. You can just see it."

Another fan praises the cast for being able to stay in character for the most part, which is no easy task given the context of the series.

"I'm always amazed the actors can maintain their composure as much as they do. There are certain scenes I've watched when I've said, literally out loud, "HOW can they keep from laughing?!!!"

Fans will be glad to know what despite the show ending a few years ago, the two remain in contact.

Kaley Cuoco And Jim Parsons Are Still Contact With Each Other And Supportive

Fans were delighted to find out that Kaley Cuoco still keeps in touch with her fellow Big Bang Theory stars via group chat.

Not only that, but Kaley also confirmed that she still maintains a friendship with Parsons, and received a text from the actor on the day of the Golden Globes.

Cuoco revealed, "Jim had sent me a text the morning of the Globes because he saw a video I posted. He was like, 'I just saw your video.' His message was very cute."

"He was very excited. It's just great for all of us because you hope that everyone's not going to be pigeonholed and everyone from the show is doing the things they want to be doing. It really wonderful, I'm thrilled."

Similar to Cuoco, Jim Parsons has taken his career in a different direction. The actor has revealed that he doesn't plan on returning to the world of TV and sitcoms, which is completely understandable given the schedule he had to maintain for over a decade on The Big Bang Theory.